“Transplantation, Autoimmunity and InflammaTion” team – TAI-IT

    Led by Prs Céline Demougeot, and Didier Ducloux,the TAI-IT team focuses on a better understanding of the immunological mechanisms at the origin of transplant rejection, those involved in the initiation and maintenance of autoimmune pathologies and/or inflammatory reactions, and the mechanisms involved in the inflammatory reaction and its resolution. This better understanding aims at the evaluation and implementation of therapeutic approaches more adapted to these physiopathologies but also at the development of innovative therapies, targeting key players in these contexts or allowing to restore control of these harmful inflammatory reactions.

    For this, the Team benefits from the expertise of many clinicians involved in the various research groups allowing access to patients and biological resources specific to these pathologies and from the expertise of these researchers mastering many experimental and biological models. Thus, the TAI-IT Team is literally dedicated to improving the treatment of these pathologies and to proposing new, innovative treatments based on this research.

    Mots clés

    Transplantation, Kidney, Immunosenescence, Autoimmune cytopenia, Vasculitis, Inflammation, GvHD, RA , IBD … Apoptosis, Efferocytosis, Macrophages, Neutrophils, Fibroblasts, Cheloids, Dermis